Meaning: Demonstrate complete power over them.
Also: Don't tread on me.
Luke 10:19
Behold, I give unto you power to tread on serpents and scorpions, and over all the power of the enemy: and nothing shall by any means hurt you.
Malachi 4:3
And ye shall tread down the wicked; for they shall be ashes under the soles of your feet in the day that I shall do this, saith the Lord of hosts.