Meaning: To make trouble. Cain was the first murderer and lost soul. Those who raise Cain are following the ways of evil.
Genesis 4:8
And Cain talked with Abel his brother: and it came to pass, when they were in the field, that Cain rose up against Abel his brother, and slew him.
1 John 3:12
Not as Cain, who was of that wicked one, and slew his brother. And wherefore slew he him? Because his own works were evil, and his brother's righteous.
Jude 1:11
Woe unto them! for they have gone in the way of Cain, and ran greedily after the error of Balaam for reward, and perished in the gainsaying of Core.